RARA（17q21）基因斷裂探針

RARA(17q21)基因斷裂探針

 廣州健侖生物科技?有限公司 

本司長(zhǎng)期供應(yīng)尼古?。商鎸帲z測(cè)試劑盒，其主要品牌包括美國(guó)NovaBios、廣州健侖、廣州創(chuàng)侖等進(jìn)口產(chǎn)品，國(guó)產(chǎn)產(chǎn)品，試劑盒的實(shí)驗(yàn)方法是膠體金方法。

我司還有很多熒光原位雜交系列檢測(cè)試劑盒以及各種FISH基因探針和染色體探針等，。

RARA(17q21)基因斷裂探針

   本試劑盒主要用于RARA(17q21)基因斷裂的檢測(cè)，里面包括即用型雜交液和DAPI復(fù)染劑。
本試劑盒僅供科研使用。

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RARA(17q21)基因斷裂探針

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 

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【騰訊 】
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室

【企業(yè)文化宣傳】RARA(17q21)基因斷裂探針

每逢佳節(jié)倍思親，大家都說(shuō)在“我的蛙”身上看到了自己，也看到了遠(yuǎn)在故鄉(xiāng)牽掛著自己的家人。
 

 
春節(jié)臨近，很多研究者們依然扎根在實(shí)驗(yàn)室忙著做實(shí)驗(yàn)，還沒(méi)回到故鄉(xiāng)與家人團(tuán)聚。一年又一年的堅(jiān)持，也許枯燥，也許辛苦，研究者們卻不改初心，因?yàn)榭蒲械哪康?，正是為了更好的服?wù)于人們的健康。
 
博奧晶典科研服務(wù)提前給大家拜個(gè)早年，也請(qǐng)大家多多關(guān)注自己和家人的健康~
 

 
今天給大家介紹一項(xiàng)前列腺癌的科研成果，研究者通過(guò)系統(tǒng)研究，發(fā)現(xiàn)DNA甲基化具有作為前列腺癌非侵入式診斷標(biāo)志物的潛力！
 
本研究鑒定了與前列腺癌有關(guān)的DNA甲基化位點(diǎn)，發(fā)現(xiàn)了6個(gè)候選的甲基化位點(diǎn)（ID：cg03052502，cg04462340，cg05163709，cg05544622，cg14466580，cg27539893），這些位點(diǎn)有以下特點(diǎn)：
1.在前列腺癌中高度特異
2.在前列腺患者尿液中檢測(cè)了其中兩個(gè)位點(diǎn)（cg05163709，cg27539893）
3.AUC-ROC分析顯示cg05163709（0.915）高于經(jīng)典的PSA（0.769）
4.在正常組織中保守，在腫瘤組織中變化顯著
5.與年齡和地理分布無(wú)關(guān)

 
研究者找到一個(gè)甲基化位點(diǎn)，cg05163709與前列腺癌密切相關(guān)，支持DNA甲基化具有成為高靈敏度和特異性的診斷標(biāo)志物的潛力。本研究中也對(duì)尿液中的DNA甲基化位點(diǎn)進(jìn)行了檢測(cè)，提示可以進(jìn)行非侵入性的甲基化檢測(cè)。
 

 
研究背景
 
用于診斷的前列腺特異抗原（PSA）檢測(cè)總是產(chǎn)生假陽(yáng)性結(jié)果，并導(dǎo)致不必要和/或重復(fù)活組織檢查。因此迫切需要開(kāi)發(fā)更靈敏更特異的診斷標(biāo)志物。本研究分析了66對(duì)癌組織和相鄰正常組織中的表觀基因型甲基化位點(diǎn)，結(jié)果發(fā)現(xiàn)，與正常組織相比，前列腺癌組織的Y染色體上有6個(gè)異常的甲基化位點(diǎn)。
 
進(jìn)一步使用PCa患者的尿液進(jìn)行焦磷酸測(cè)序，發(fā)現(xiàn)一個(gè)甲基化位點(diǎn)（cg05163709）是潛在的生物標(biāo)志物。通過(guò)ROC分析評(píng)估了這些異常甲基化位點(diǎn)的預(yù)測(cè)能力，發(fā)現(xiàn)cg05163709（0.915）的AUC高于PSA的AUC（0.769）。這些結(jié)果表明Y染色體上的cg05163709異常DNA甲基化具有成為高靈敏度和特異性的診斷標(biāo)志物的潛力。
 

Whenever we think about the family, everyone says they see themselves on my frog and see their family in their hometown.

When the Spring Festival is approaching, many researchers are still working in the laboratory to do experiments and have not returned to their hometown to reunite with their families. Year after year's insistence may be boring, maybe hard, but researchers do not change their minds, because the purpose of scientific research is to better serve people's health.

Boao crystal code research service in advance for everyone a happy, also please pay more attention to the health of themselves and their families.

Today we introduce a scientific research achievement of prostate cancer. Through systematic research, researchers found that DNA methylation has potential as a noninvasive diagnostic marker for prostate cancer.

This study identified DNA methylation sites related to prostate cancer, and found 6 candidate methylation sites (ID:cg03052502, cg04462340, cg05163709, cg05544622, cg14466580, cg27539893). These loci have the following characteristics.
1. highly specific in prostate cancer
2. the two loci (cg05163709, cg27539893) were detected in the urine of the prostate patients.
The 3.AUC-ROC analysis showed that cg05163709 (0.915) was higher than the classic PSA (0.769).
4. conservative in normal tissues and significant changes in tumor tissue
5. has nothing to do with age and geographical distribution

The researchers found a methylation site. Cg05163709 is closely related to prostate cancer. DNA methylation is a potential marker for high sensitivity and specificity. In this study, the DNA methylation sites in urine were also detected, suggesting that noninvasive methylation can be detected.

Research background

The detection of prostate specific antigen (PSA) used for diagnosis always produces false positive results and leads to unnecessary and / or repeated biopsy. Therefore, it is urgent to develop more sensitive and specific diagnostic markers. In this study, 66 pairs of epigenetic methylation sites in cancer tissues and adjacent normal tissues were analyzed. It was found that there were 6 abnormal methylation sites on Y chromosome of prostate cancer tissues compared with normal tissues.

The urine of PCa patients was further sequenced by pyrophosphate, and a methylated site (cg05163709) was found to be a potential biomarker. The predictive ability of these abnormal methylation sites was evaluated by ROC analysis, and it was found that the AUC of cg05163709 (0.915) was higher than AUC (0.769) of PSA. These results suggest that the cg05163709 abnormal DNA methylation on the Y chromosome has the potential to be a highly sensitive and specific diagnostic marker.